Genomic aberrations relate early and advanced stage ovarian cancer

Background

Because of the distinct clinical presentation of early and advanced stage ovarian cancer, we aim to clarify whether these disease entities are solely separated by time of diagnosis or whether they arise from distinct molecular events.

Methods

Sixteen early and sixteen advanced stage ovarian carcinomas, matched for histological subtype and differentiation grade, were included. Genomic aberrations were compared for each early and advanced stage ovarian cancer by array comparative genomic hybridization. To study how the aberrations correlate to the clinical characteristics of the tumors we clustered tumors based on the genomic aberrations.

Results

The genomic aberration patterns in advanced stage cancer equalled those in early stage, but were more frequent in advanced stage (p?=?0.012). Unsupervised clustering based on genomic aberrations yielded two clusters that significantly discriminated early from advanced stage (p?=?0.001), and that did differ significantly in survival (p?=?0.002). These clusters however did give a more accurate prognosis than histological subtype or differentiation grade.

Conclusion

This study indicates that advanced stage ovarian cancer either progresses from early stage or from a common precursor lesion but that they do not arise from distinct carcinogenic molecular events. Furthermore, we show that array comparative genomic hybridization has the potential to identify clinically distinct patients.     

糖尿病合并高血压患者血糖、血压水平与动脉硬化的相关性研究

目的 探讨糖尿病合并高血压患者血糖血压水平与动脉硬化的关系。方法 以北京某农村社区40岁及以上糖尿病合并高血压患者为研究对象,对患者进行问卷调查、体格检查、肱踝脉搏波传导速度（baPWV）检测和血样检测。根据患者糖化血红蛋白（HbA1c）、收缩压（SBP）及舒张压（DBP）水平进行分组,采用Logistic回归模型分析血糖血压水平与动脉硬化的关系。结果 共纳入1214例患者,其中动脉硬化异常（baPWV≥1700cm/s）有637人,占52.47%。相关性分析显示baPWV与HbA1c （r_s=0.174,P=0.000）、SBP （r_s=0.481,P=0.000）及DBP （r_s=0.167,P=0.000）均呈正相关。Logistic回归分析显示,调整其他危险因素后,HbA1c和SBP每增加1个四分位数间距动脉硬化异常风险分别为1.41倍（95% CI：1.16~1.70）和3.71倍（95% CI：2.80~4.91）。结论 糖尿病合并高血压患者baPWV与HbA1c及SBP显著相关,同时控制血糖和血压可能有利于降低动脉硬化异常发生风险。